VCheng
THINK TANK: CONSULTANT
Asim Munir himself is behind damaging Imran Khan's right eye.
Medically impossible. Any old person with several possible systemic problems would be prone to having such issues by natural aging.
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Central Retinal Vein Thrombosis (CRVO) happens when the main vein draining blood from the retina becomes blocked by a clot — essentially a stroke of the eye. The causes are best understood in 4 major categories:
1.
These account for the majority of CRVO cases, especially in patients >50 years old:
Hypertension
Diabetes mellitus
Hyperlipidemia
Atherosclerosis
Smoking
Obesity
Advanced age
Why?
Atherosclerotic thickening of the central retinal artery compresses the adjacent central retinal vein at the lamina cribrosa → turbulent flow → clot formation.
2.
Especially important in younger patients (<50) with CRVO:
Factor V Leiden mutation
Prothrombin gene mutation
Protein C or S deficiency
Antithrombin III deficiency
Antiphospholipid syndrome
Hyperhomocysteinemia
Polycythemia vera
Essential thrombocythemia
Oral contraceptive use / estrogen therapy
Think of these when:
CRVO occurs in a patient with no hypertension or diabetes
3.
Glaucoma
Elevated intraocular pressure
Optic nerve head crowding
Ocular inflammation (uveitis)
Trauma
Raised IOP reduces venous outflow → promotes venous stasis.
4.
Less common but important:
Vasculitis (e.g., SLE, Behçet disease)
Sarcoidosis
Temporal arteritis
Severe dehydration
Malignancy-associated hypercoagulability
Clinical Pearl (Exam & Real Life)
Age Group Most Likely Cause
> 50 yrs HTN / DM / Atherosclerosis
< 50 yrs Hypercoagulable state
Any age + glaucoma IOP-related venous stasis
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