Israel's mouthpiece in America are people like Lindsey Graham. It was significant that Graham, in an official hearing, openly targeted Pakistan for allegedly sheltering the Iranian jets on Pakistani airbases. And recently Graham has shown his displeasure over the upcoming MOU, which will be hosted by Pakistan in Geneva.
So far, I believe, historically Pakistan and Israel have not been openly hostile to each other as both have their hands full in their respective regions. But in the new order emerging where the Israelis are rightly cautious of the nascent regional alliance involving Pakistan, there is no doubt in my mind that the relations will be more hostile between Pakistan and Israel. And we all know where India stands in the regional order.