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Is COVID-19 a Seasonal Virus Yet?​

4 MINUTE READ
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BY ALICE PARK
MARCH 6, 2024 10:19 AM EST
The most common respiratory viruses that cause flu, colds, and RSV tend to cluster in the fall and winter months. Though that means months of elevated risk for sickness, "cold and flu season" is a convenient time for public-health officials to remind people to get vaccinated and wash their hands more frequently.
Experts had hoped that COVID-19 would follow that same pattern, but so far, that's not the case.

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COVID-19 occurs in every season​

Both flu and RSV tend to plummet to near negligible levels in spring and summer before surging again in the fall and winter. COVID-19 does not seem to fall into that same seasonal pattern.
While COVID-19 cases also peak during the winter season, they persist throughout the spring and summer at a lower but still significant level. “We do not see COVID-19 reach the same low levels as influenza and RSV during the late spring and summer,” says Andrew Pekosz, professor of molecular microbiology and immunology at Johns Hopkins Bloomberg School of Public Health. “That’s why we can’t treat this like flu, because we are not seeing it go away like we see with flu. There is going to be a risk of getting COVID-19 year-round.”
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The U.S. Centers for Disease Control and Prevention (CDC) nodded to the lack of seasonality of COVID-19 when it recently updated its vaccination guidance for older people. It advised those over 65—the age group that is currently developing more severe disease and requiring hospitalization most often—to get a second dose of the latest COVID-19 vaccine in the spring, at least four months after their first shot in the fall or winter. “We’re always driven by the data, and so far it looks like COVID-19 is not going to disappear in the spring and summer like flu and RSV," says Dr. Wilbur Chen, professor of medicine at the University of Maryland School of Medicine and a member of the CDC committee that recommended the additional vaccine dose.

But it could start acting more like a winter virus​

We are at a transitional period with COVID-19 right now, Pekosz says. As people continue to rack up more infections, vaccine doses, or both, their immunity and defenses to the once-novel virus grow. That means that on a population level, the virus is finding fewer targets to infect. Even as it morphs into different variants, past infections and shots have offered protection (so far).

For most people, therefore, COVID-19 is slowly becoming more like a seasonal disease in which their risk of infection is highest during the winter months. That helps explain the CDC’s other recent decision to relax isolation guidelines for people who have COVID-19, moving away from a five-day isolation period after someone tests positive to allowing them to resume public activities 24 hours after they no longer have symptoms such as a fever. This approach is more in line with how people treat the common cold and flu.
Over time, it's possible that COVID-19 infections could cluster in the winter, when people spend more time indoors and the virus has more opportunity to spread. The cold, dry air also encourages transmission. "If we look at other pandemics, it takes several years for a virus to settle into a seasonal pattern that resembles what we see with flu and RSV," Pekosz says. "I think we’re moving in that direction, but we’re certainly not there yet.”





That's why people at high risk of complications still "need tools to protect themselves better, like an additional dose of vaccine," he says. However, "the majority of the general population can start to treat COVID-19 a little more like a seasonal infection," he says.
 

COVID-19 hospitalizations drop in weekly BCCDC update​

Summary by Ground News
There were 148 test-positive patients in B.C. hospitals across the province as of Thursday. That's a decrease of 15 per cent or about nine per cent from the 163 reported in hospital at this time last week. The latest data continues the trend of relatively stable hospitalization levels seen throughout 2024 so far.
 

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Weekly case numbers from around Australia: 5,140 new cases (🔻5%), 771 hospitalised, 8 in ICU​

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Australia: Case Update
  • NSW 1,462 new cases (🔻3%); 384 hospitalised
  • VIC 620 new cases (🔺4%); 156 hospitalised; 5 in ICU
  • QLD 1,148 new cases (🔺2%); 169 hospitalised
  • WA 223 new cases (🔻13%); 19 hospitalised; 2 in ICU
  • SA 1,070 new cases (🔻14%)
  • TAS 524 new cases (🔻13%); 27 hospitalised
  • ACT 62 new cases (🔺44%); 16 hospitalised; 1 in ICU
  • NT 31 new cases (🔻11%); 0 hospitalised
Notes:
  • Older more detailed surveillance reports can be accessed using the state and territory links above.
  • These case numbers are only an indicator for the current trends as most cases are unreported.
  • Multiply by 20 or 30 to get a better indication of actual community case numbers.
  • NSW, VIC, QLD, WA and the ACT no longer collect or report RAT results.
Data is sourced from CovidLive that pulls data from the NNDSS Dashboard for case numbers (updated daily) and the National Dashboard for hospitalisations (updated monthly).
Flu tracker tracks cold and flu symptoms (fever plus cough) and is another useful tool for tracking the level of respiratory viruses in the community.
General case numbers and hospitalisations are still dropping on the east coast, but VIC is seeing a small uptick in wastewater readings and reported cases. RSV and influenza rates are starting to show signs of an uptick (but still at low levels).
r/CoronavirusDownunder - Weekly case numbers from around Australia: 5,140 new cases (🔻5%), 771 hospitalised, 8 in ICU
 

Long Covid may be nothing unique in the future – but its effects today are still very real​

Gideon Meyerowitz-Katz


While the long-term risk from a current infection is 10 times less than it was in 2020-21, a lot of people are still suffering after getting Covid early in the pandemic
Fri 22 Mar 2024 23.00 GMT
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Long Covid is one of the most controversial topics remaining about the pandemic. Depending on who you ask, it is either a real and current threat to the health of the globe, or a relatively minor issue that we should pay little attention to in the future. It is hard to weigh in on the topic without passionate advocates taking issue with the things that you say, which is true of quite a lot of the conversations we have had over the course of the pandemic.
There are two separate long Covid conversations going on at the same time

A recent study from Queensland has injected further discord into this already complicated space. The press release about the study says that, in a large observational study, people who had tested positive for Covid-19 when the Omicron variant was spreading were no more likely to report ongoing symptoms or serious problems in their daily life than either people who tested negative or those who tested positive for influenza. This follows similar previous work by the same team showing almost identical results. According to Dr John Gerrard, one of the authors of the paper and Queensland’s chief health officer, the findings call into question the entire conceptualisation of long Covid, arguing that it may be “time to stop using terms like ‘long Covid’”.

This has caused a number of articles arguing that long Covid is causing unnecessary fear, because of little difference between long-term symptoms caused by Covid-19 and other common viral infections.
The first issue here is that it’s hard to know what to make of the research. The results being reported are an early news release about a presentation that is going to happen at the European Congress of Clinical Microbiology and Infectious Diseases in April. In other words, we have no idea how robust this paper is, nor how useful the data may be. The fact that there are so many news stories about this unpublished, unpresented finding is itself something of a problem.

Nurses at Queensland hospital
Time to stop using term ‘long Covid’ as symptoms no worse than those after flu, Queensland’s chief health officer says
Read more

However, the reports on these findings are consistent with a range of other papers that have been published on Covid-19 in the last few years. We know that the risk of long Covid is strongly related to how severe initial infections are. In 2020, when Covid-19 was many times more problematic than flu, long Covid was fairly common, but after successful vaccination campaigns, effective new medications and wide-scale infection, the risk from a Covid-19 infection has gone down substantially. The risk of getting long Covid from an infection is now somewhere around 10times less common than it was in 2020. Given the decrease in severity of Covid-19, it’s not unlikely that rates of long-lasting symptoms are similar between Covid-19 and influenza in 2024. As I’ve been saying for years, much of this comes down to how we define long Covid, and how we know which long-term symptoms are actually caused by Covid-19.

In other words, you could reasonably argue that Dr Gerrard is correct. The problem, however, is that a lot of people were infected in 2020 and 2021, before we had vaccines and treatments to reduce the severity of the disease. There is no question that a large group of people are still suffering serious problems from their initial Covid-19 infection, many of them years after first getting sick. Australia doesn’t have a national estimate of how many, but data from the UK suggests that about 0.5% of the country might fall into this group. While it’s not a big percentage, that is still a lot of people – a similar rate in Australia would mean about 100,000 Aussies suffering similarly. These people have been left largely without hope, because we still don’t really know why they have long Covid, and have no effective interventions to treat their disease.
And herein lies the problem with long Covid discussions. There are two separate conversations going on at the same time. We can talk about the future, which seems a bit brighter – long Covid rates are down drastically, and people who get infected with Covid-19 now are about as likely to experience serious, long-lasting issues as people who got the flu in 2019. But we also have to acknowledge the large number of people seriously injured by Covid-19 in the early stages of the pandemic who may never recover their health.
There may be nothing unique about long Covid in the future – even without this new report the evidence is strong that Covid-19 is now quite similar in risk to influenza per infection – and perhaps we should start talking more about post-viral conditions as a category rather than focusing on those symptoms caused by Covid-19 alone. But if we do, it is important that we do not leave behind the numerous people suffering seemingly endless problems caused by Covid-19 years ago.
Gideon Meyerowitz-Katz is an epidemiologist working in chronic disease in Sydney’s west, with a particular focus on the social determinants that control our health
 

Here's who should get a COVID-19 booster: INSPQ​

Dr. Nicholas Brousseau of Quebec's public health institute explains who should get a COVID-19 booster this spring.
March 22, 2024 7:14 p.m. EDT
 

COVID Tracker | Cases fall for fifth straight week; state changes reporting​

March 19, 2024
Bridge Staff
Michigan Health Watch
Coronavirus Michigan

Bridge Michigan
Michigan Health Watch
COVID Tracker | Cases fall for fifth straight week; state changes reporting

Last updated: Tuesday, March 19, at 5:31 p.m. This post will be continuously updated with Michigan coronavirus locations and updated COVID-19 news.

For more interactive maps and charts, see the Michigan Coronavirus Dashboard, showing vaccine distribution information, case numbers, locations, deaths and demographics.
Michigan reported 1,369 confirmed and probable COVID-19 cases Tuesday, down from the 1,848 confirmed cases reported last week.
The state reported 35 additional deaths.
The Michigan Department of Health and Human Services this week discontinued reporting confirmed and probable cases, instead reporting an aggregate of the two.
Bridge Michigan had only used confirmed cases since the pandemic began in March 2020.
In making the change, the state’s reported case total is now 3.3 million since the pandemic began, including 521,000 probable cases and 2.7 million confirmed cases. There have been a 44,763 confirmed and probable COVID-19 deaths; of those, 40,170 were confirmed cases, according to last week’s data.
COVID-19 reporting has changed across the country, both by states and the media, few of which report weekly cases and deaths. Many stopped last May when the federal COVID-19 health emergency ended May 11, 2023.
The number of confirmed COVID-19-positive hospital patients fell Monday to 331, the lowest since 289 were reported Sept. 1, 2023.
Experts say that state reported cases are likely a vast undercount because many people either no longer test for the virus when they have symptoms or rely on home tests.— Mike Wilkinson

Tuesday, March 12​

Cases fall 24%​

Michigan reported 1,848 weekly confirmed COVID-19 cases Tuesday, down 24% from 2,434 last week.
The decline comes as the number of confirmed COVID-19-positive hospital patients fell Monday to 410, the lowest since 396 were reported Sept. 11, 2023. Hospitalizations peaked this year at 1,275 on Jan. 3.
The state also reported 66 additional COVID-19-positive deaths, a 10% increase from the 60 reported last week. Of the new deaths, 31 occurred in March, 34 in February and 3 in January.
Related: Michigan bottle returns fall after COVID, prompting get-tough push on grocers
So far, there have been 493 COVID-19 deaths in 2024.
Experts say that state-confirmed cases are likely a vast undercount because many people either no longer test for the virus when they have symptoms or rely on home tests. Still, case counts are an indication of overall trends.— Mike Wilkinson
 

Last updated 2pm 18 March 2024.
This data is updated weekly. All data on this page relates to cases recorded prior to 11:59 pm 17 March 2024.

COVID-19 cases summary​

New case average* RATs uploaded average*
667 ↓ 211 ↑
Cases in hospital as at midnight SundayCases in ICU as at midnight Sunday
155 **
Deaths attributed to COVID*Total deaths attributed COVID
3 3,902
* 7 day rolling average
** Not currently available

Current situation​

Summary
In the last weekNew cases reported4666
Reinfections3012
Reinfections (< 90 days)34
Total since first New Zealand caseCases reported2613670
Reinfections350103
Reinfections (< 90 days)26201

Case outcomes since first New Zealand case

COVID-19 casesChange in the last weekTotal
Recovered47772605102
Deceased*203902*
*The Ministry of Health has recently switched its definition of 'deceased' from deaths within 28 days of testing positive for COVID-19 to deaths attributed to COVID-19. See the definitions section below for further details.

Deaths with COVID-19​

Cause of deathDied within 28 days of positive testDied more than 28 days after positive testTotalChange in the last week
COVID as underlying2330117244715
COVID as contributory135310214555
COVID-attributed total3683219390220
Not COVID17610*176114
Not available23002302
Total5674219589336*
*The change in total deaths with COVID may not be equal to the number of new deaths reported today. This is because deaths that occurred more than 28 days after a positive test that are subsequently determined to be unrelated to COVID are removed from the total.
Of the 36 people whose deaths we are reporting today: two were from Northland, ten were from Auckland region, three were from Waikato, two were from Bay of Plenty, two were from Hawke's Bay, two were from Taranaki, one was from MidCentral, one was from Whanganui, two were from Wellington region, one was from Nelson Marlborough, two were from Canterbury, eight were from Southern.
One was less than 10 years old, one was in their 40s, one was in their 60s, seven were in their 70s, 16 were in their 80s and ten were aged over 90. Of these people, 20 were women and 16 were men.

Case details​

Number of active cases
Change in the last weekTotal since first NZ case
Confirmed8002500615
Probable3865113055
Total4665*2613670
*The change in total case numbers may not be equal to the number of new cases reported today due to data updating and reconciliation.

Definitions​

Active case - confirmedConfirmed cases are people who have received a positive PCR test OR someone who has received a positive result on a Rapid Antigen Test. For more details, see the COVID-19 case definition.
Active case - probableA probable case is when someone is diagnosed based on their exposure to other people with COVID-19 and on their symptoms.
ReinfectionsReinfections are cases in an individual who reported a case 29 or more days previously.
RecoveredRecovered cases are people who had the virus, where at least 7 days have passed since their symptoms started and they have not had symptoms for 72 hours, and they have been cleared by the health professional responsible for their monitoring.
DeceasedIncludes all deaths where COVID-19 is determined to have been the underlying cause of death or a contributory cause of death.

Cases reported each day​

Daily confirmed and probable cases​

New COVID-19 cases reported each day

This graph shows the count of all cases of COVID-19 every day (all cases – confirmed and probable) since the first New Zealand case in late February 2020. The graph shows the rapid increase of daily cases from mid-February 2022 to early March 2022, driven by the Omicron variant. From mid-March to mid-April 2022, cases rapidly declined, followed by a period of slower decline until early July. This was followed by a rapid increase in cases, peaking in August before a steady decline in new daily cases. Reported new daily cases hit their lowest since February 2022 in September 2022.
New COVID-19 cases reported each day
This graph shows the count of all cases of COVID-19 every day (all cases – confirmed and probable) since the first New Zealand case in late February 2020. The graph shows the rapid increase of daily cases from mid-February 2022 to early March 2022, driven by the Omicron variant. From mid-March to mid-April 2022, cases rapidly declined, followed by a period of slower decline until early July. This was followed by a rapid increase in cases, peaking in August before a steady decline in new daily cases. Reported new daily cases hit their lowest since February 2022 in September 2022.

COVID-19 by location​

Total cases by location​

Total COVID-19 cases by location graph

This bar graph shows the total cases and their status by health district and those with recent travel history.
The ‘At the border’ data group includes cases detected in managed isolation or quarantine facilities from the period when these were operating, as well as cases with recent travel history from after that time. They are not included in the district totals. Before 17 June, people in managed isolation or quarantine facilities were included in the total of the relevant district.
Total COVID-19 cases by location graph
This graph shows:
  • This bar graph shows the total cases and their status by health district and those with recent travel history.
    The ‘At the border’ data group includes cases detected in managed isolation or quarantine facilities from the period when these were operating, as well as cases with recent travel history from after that time. They are not included in the district totals. Before 17 June, people in managed isolation or quarantine facilities were included in the total of the relevant district.

Total cases by location​

LocationActiveRecoveredDeceasedTotalNew cases in the last week
Auckland387245539262246188385
Bay of Plenty149114730181115060150
Canterbury665344760543345968665
Capital and Coast506184461173185140507
Counties Manukau396292224314292934397
Hawke's Bay1328586416686162133
Hutt Valley226902579890581225
Lakes83512091115140383
Mid Central1799614820696533178
Nelson Marlborough1337928715679576133
Northland1418083814281121142
South Canterbury4834587443467948
Southern404191432370192206404
Tairāwhiti5726529432662956
Taranaki1196551512865762119
Unknown92243922619
Waikato369207657387208413369
Wairarapa6425456632558364
Waitematā482308978401309861482
West Coast2115753211579521
Whanganui9634343783451796
At the Border*027292627298NA
Total46662605102390226136704666
* Due to retiring the COVID-19 Protection Framework on 12 September 2022, the Ministry of Health no longer separately reports COVID-19 cases who have recently travelled overseas. These cases will be included in the weekly reporting on all COVID-19 community cases, but we will no longer distinguish between border and other cases.
You can also view a detailed breakdown of daily case numbers for each district since the beginning of the pandemic by clicking the ‘download’ button on the right hand side of this page: New Zealand COVID-19 data.

Note: we cannot give detailed information about cases in your district, city or town, as we must protect the privacy of the people concerned.
 

COVID vaccines don’t cause cancer. But false claims persist in sea of misinformation​


20240322110356-65fdaa296d3494155e720cb8jpeg.jpg

FILE - A health worker administers a dose of COVID-19 vaccine during a vaccination clinic in Reading, Pa. On Friday, Oct. 7, 2022 The Associated Press reported on stories circulating online incorrectly claiming COVID-19 mRNA vaccines alter recipients’ DNA by changing its shape to a “triple helix.” (AP Photo/Matt Rourke, File) Copyright 2021 The Associated Press. All rights reserved.
By Sonja Puzic, The Canadian Press
Posted March 23, 2024 4:00 am.

Last Updated March 23, 2024 8:34 am.
Anyone who spends even a moderate amount of time online has likely come across social media posts falsely claiming that COVID-19 vaccines are harmful to human health.
Among the most widely debunked claims is that vaccines developed with messenger RNA technology can cause cancer because they contain “monkey virus DNA.”

Such claims were even repeated during a U.S. congressional hearing on vaccine injuries last year, but North American and European health authorities have stressed that there is no proof of a causal link between COVID vaccines and cancer, or that mRNA vaccines can alter human DNA in any way.
A senior policy analyst with the Canadian Cancer Society also debunked such claims while noting the added harm of false beliefs is that they can derail the deployment of proven therapies.


“Misinformation can increase vaccine hesitancy and can delay the provision of health care,” Apiramy Jeyapalan said in an emailed statement.
The fact that cancer patients and others may still be exposed to that kind of misinformation online and elsewhere is very concerning and shouldn’t be ignored by the medical and scientific community, says a Canadian scientist whose areas of expertise include health literacy.
Cheryl Peters, a senior scientist at BC Cancer and the BC Centre for Disease Control, said going through cancer treatment is “a highly vulnerable time,” especially for patients who are feeling overwhelmed and may be susceptible to information from dubious sources.
“We have to be aware that these things are circulating and be aware that our friends and family could be getting exposed to these conspiracy theories that might really actually materially harm them if they listen to them,” Peters said.
She noted that people who spread vaccine misinformation online attribute all sorts of things – from heart attacks to sudden deaths – to COVID shots. So when it comes to false claims, for example, that the vaccines are also the reason younger age groups are seeing higher rates of certain types of cancer than previously, “your Spidey senses should go up.”
“There’s no sort of one exposure to something — whether it be a vaccine or other (things) — that’s going to be able to cause every single kind of negative health outcome. That’s just not how our biology works,” Peters said.
Dr. Aaron Schimmer, director of research at the Princess Margaret Cancer Centre in Toronto, said he believes the level of misinformation surrounding COVID vaccines has decreased over time, but acknowledged that false claims still creep up.
“I think a number of patients, especially around the time when the vaccines were introduced, if they were newly diagnosed with cancer around that time … would say, ‘Well, you know, my cancer was caused by the vaccine.’ Of course, again, biologically that’s not true. Those cancers have been there probably growing slowly (over) many years,” he said.
Schimmer, who mainly treats leukemia in his clinical practice, said none of his own patients have raised specific conspiracy theories about vaccines and cancer, “but I’ve definitely had patients who’ve had concerns about the vaccine, the safety and questions as to whether the vaccine was the trigger for their cancer.”
The irony, Schimmer said, is that mRNA vaccines were being tested as potential cancer treatment long before the COVID pandemic hit. The idea is that mRNA could train an individual’s immune system to target specific cancer cells.
“It was the investments that were being made at the time to understand how these may work as cancer treatments that actually allowed us to generate a COVID vaccine so quickly,” he said.
Peters, the BC Cancer scientist, said mRNA vaccines have great value and there is promising work to be done with them in the future. But she wonders if the science behind that is being properly translated and communicated to the masses.
“That’s a bit of an existential question for science in general, I think,” she said.
Samara Perez, a clinical psychologist in the psychosocial oncology department of McGill University Health Centre in Montreal, says the vast majority of patients consider doctors and health-care professionals to be the most trusted sources of information, and research over the years has backed that up.
Even though a cancer diagnosis can set off a range of psychological responses, such as depression and anxiety, Perez does not believe a particular vulnerability to misinformation is among them.
“I think people that are susceptible to misinformation prior to (getting) cancer would be the same after,” said Perez, who is also a professor at McGill University, noting that she debunks any cancer myths raised by her patients “right away.”
Both Schimmer and Peters said there’s nothing wrong with a healthy dose of skepticism when it comes to making personal medical choices. Peters said she also understands why some patients – especially those from historically marginalized communities – distrust the system.
But that’s where doctors, scientists and health-care authorities have to step up and ensure that they are being upfront about the rare, but real, vaccine side-effects and other potential negative outcomes, she said, noting that transparency goes a long way toward building trust.
A study co-authored by Peters and published earlier this year found that Canadians were better at identifying known cancer risk factors, such as tobacco use, than recognizing cancer myths.
For example, more than half of survey respondents incorrectly believed that stress and consuming additives increases cancer risk. Between 20 and 30 per cent believed risk is increased by wearing deodorant, using hair dye, living near power lines and “having bad luck.” But the vast majority of respondents did not believe that vaccination, in general, is a risk factor.
Peters believes that myths and misinformation now play a bigger role in health-care choices people make than in the past because “we all have basically unlimited access to information” – and some people are intentionally peddling false claims online so they can profit from unproven “remedies.”
“And that, I think, is not a problem that’s going away,” Peters added. “Cancer patients and other people with chronic conditions really need support.”
The Canadian Cancer Society advises people to approach unverified sources of information with caution. On its website, the society aims to dispel some common myths – such as the belief that certain foods can prevent or cure cancer – and urges people who have questions or are unsure about something to call its cancer information helpline.
“For people with cancer, talk to your health-care team about which of the approved COVID-19 vaccines is right for you, and to determine the best timing of the doses based on your unique circumstance,” the society said in a statement.
 

Waterloo Region senior dies of COVID-19 as flu hospitalizes a greater number of patients​

There are currently twice as many patients in local hospitals with influenza than with COVID-19
Jeff-Outhit
ByJeff OuthitReporter
Friday, March 22, 2024
1 min to read
Article was updated 20 hrs ago
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COVID-19 vaccine

65e22f647e80d.image.jpg

Syringes and vials of COVID-19 vaccine are seen in this file photo.
The Canadian Press file photo


A woman in her 90s has died of COVID-19, raising the pandemic toll to 12 deaths this year.
The regional public health unit reported the latest death Friday in a weekly update of indicators. The health unit counts cases where the pandemic disease is a main or contributing cause of death.
Hospitalizations are stable at a relatively low level. There are currently six patients with COVID-19 in three local hospitals on an average day. A typical day during the four-year pandemic is 26 patients hospitalized.

No new outbreaks were reported in high-risk settings. Records show two active outbreaks are ongoing in Waterloo Region retirement homes.


Sewage monitoring points to a stable, relatively low level of coronavirus infection in Kitchener and in Cambridge.
Influenza patients surpassed COVID-19 patients early in March. There are currently 12 patients hospitalized with flu on an average day, twice the number of patients with COVID-19.
 

FDA authorizes new drug to protect immune compromised from Covid-19​

  • Jason Mast
By Jason Mast March 22, 2024
Reprints
The FDA building -- First Opinion coverage from STAT
ADOBE
The Food and Drug Administration on Friday authorized a new antibody to protect immunocompromised individuals against Covid-19.

The drug, known as Pemgarda and marketed by the biotech Invivyd, is the first such drug to become available since the agency pulled AstraZeneca’s Evusheld off the market in January 2023. New Omicron variants had rendered Evusheld ineffective.

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Some immunocompromised patients — a group that includes certain cancer patients, patients with some autoimmune or genetic disorders, and organ transplant recipients — have been eagerly awaiting the new prophylactic. Because their condition or drugs they take for it weaken their immune systems, they don’t always get adequate protection from vaccination. Antibody treatments can add additional protection.

There remains a need for additional Covid protections. Last week, over 10,000 patients with Covid-19 were admitted to U.S. hospitals.

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Still, it’s not clear how many patients will avail themselves of the new treatment. Invivyd, the drug’s developer, estimated there are 9 million immunocompromised people in the U.S., but its initial focus will be on the 485,000 with the most acute need: Stem cell transplant recipients, organ transplant recipients, and blood cancer patients.

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Evusheld itself had gone vastly underused when it was available, prompting the federal government to launch efforts to educate the public about its existence. And the need is probably less acute now for some: Although immunocompromised patients have a reduced response to vaccination, many may still gain some protection from multiple rounds of vaccination and exposure to the virus. Uptake for other measures to mitigate Covid risk, such as boosters and Paxlovid upon infection, has also declined precipitously, despite public health efforts.

“We will explore having it available at our institution, so that our very compromised patients and the services and specialities that take care of those patients know that it’s an option,” said Priya Nori, an infectious disease specialist at Albert Einstein College of Medicine. “But we’re not expecting gangbusters in terms of interest.”

Invivyd has not yet disclosed a price.

The company was originally founded in 2020 by antibody expert Tillman Gerngross, under the name Adagio, and raised $309 million in an IPO a year later. But the company’s original antibody — which had been designed to be all but variant-proof — was soon rendered ineffective by the advent of Omicron, eventually leading to Gerngross’s resignation and a series of high-level changes at the company.

Pemgarda is a re-engineered version of the original antibody, designed to cover Omicron variants. That gave Invivyd a faster path to getting a new preventative on the market than competitors who started from scratch.
 

Flu surpasses COVID for number of hospitalizations in region​

COVID-19 claims an elderly patient
CambridgeToday Staffabout 19 hours ago





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The number of patients in hospital suffering from the effects of influenza surpassed COVID patients this week.
The latest update on the Region of Waterloo's respiratory disease surveillance dashboard shows nine patients are in hospital with flu while six are in hospital with COVID.


COVID resulted in one death over the last week, a woman in her 90s. It brings the total number of COVID deaths so far this season to 31.
There have only been four outbreaks of influenza in high-risk settings the entire season. COVID-19 outbreaks have been declared in 142 instances while three outbreaks are ongoing.
There were 25 recent cases of flu and 36 recent cases of COVID.
Wastewater data up to March 18 shows COVID-19 has plateaued with variability in Kitchener and Cambridge.
The total number of reported influenza cases in the region since the season began is 615 while 2,623 cases of COVID-19 were reported.
There are no cases of respiratory syncytial virus (RSV) in the region.
 

Severe lung infection during COVID-19 can cause damage to the heart​

NIH supported study shows that the virus that causes COVID-19 can damage the heart without directly infecting heart tissue.

SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-supported study has found. The research, published in the journal Circulation, specifically looked at damage to the hearts of people with SARS-CoV2-associated acute respiratory distress syndrome (ARDS), a serious lung condition that can be fatal. But researchers said the findings could have relevance to organs beyond the heart and also to viruses other than SARS-CoV-2.

Scientists have long known that COVID-19 increases the risk of heart attack, stroke, and Long COVID, and prior imaging research has shown that over 50% of people who get COVID-19 experience some inflammation or damage to the heart. What scientists did not know is whether the damage occurs because the virus infects the heart tissue itself, or because of systemic inflammation triggered by the body’s well-known immune response to the virus.

“This was a critical question and finding the answer opens up a whole new understanding of the link between this serious lung injury and the kind of inflammation that can lead to cardiovascular complications,” said Michelle Olive, Ph.D., associate director of the Basic and Early Translational Research Program at the National Heart, Lung, and Blood Institute (NHLBI), part of NIH. “The research also suggests that suppressing the inflammation through treatments might help minimize these complications.”

To reach their findings, the researchers focused on immune cells known as cardiac macrophages, which normally perform a critical role in keeping the tissue healthy but can turn inflammatory in response to injury such as heart attack or heart failure. The researchers analyzed heart tissue specimens from 21 patients who died from SARS-CoV-2-associated ARDS and compared them with specimens from 33 patients who died from non-COVID-19 causes. They also infected mice with SARS-CoV-2 to follow what happened to the macrophages after infection.

In both humans and mice, they found the SARS-CoV-2 infection increased the total number of cardiac macrophages and also caused them to shift from their normal routine and become inflammatory.

When macrophages are no longer doing their normal jobs, which includes sustaining the metabolism of the heart and clearing out harmful bacteria or other foreign agents, they weaken the heart and the rest of the body, said Matthias Nahrendorf, M.D., Ph.D., professor of Radiology at Harvard Medical School and senior author on the study.

The researchers then designed a study in mice to test whether the response they observed happened because SARS-CoV-2 was infecting the heart directly, or because the SARS-CoV-2 infection in the lungs was severe enough to render the heart macrophages more inflammatory. This study mimicked the lung inflammation signals, but without the presence of the actual virus. The result: even in the absence of a virus, the mice showed immune responses strong enough to produce the same heart macrophage shift the researchers observed both in the patients who died of COVID-19 and the mice infected with SARS-CoV-2 infection.

“What this study shows is that after a COVID infection, the immune system can inflict remote damage on other organs by triggering serious inflammation throughout the body – and this is in addition to damage the virus itself has directly inflicted on the lung tissue,” said Nahrendorf. “These findings can also be applied more generally, as our results suggest that any severe infection can send shockwaves through the whole body.”

The research team also found that blocking the immune response with a neutralizing antibody in the mice stopped the flow of inflammatory cardiac macrophages and preserved cardiac function. While they have yet to test this in humans, Nahrendorf said a treatment like this could be used as a preventive measure to help COVID-19 patients with pre-existing conditions, or people who are likely to have more severe outcomes from SARS-CoV-2 associated ARDS.

Funding: This study was supported by NHLBI grants: HL139598, HL142494, HL155097, and HL149647.

About the National Heart, Lung, and Blood Institute (NHLBI): NHLBI is the global leader in conducting and supporting research in heart, lung, and blood diseases and sleep disorders that advances scientific knowledge, improves public health, and saves lives. For more information, visit www.nhlbi.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
 

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