They cannot even stop Iran, and Iran has an embryonic programme. You cant kill knowledge.
For sure Israel and US find Paks nukes a nusience, only a full scale invasion could completely get rid of the programme now, It is simply too large and Pakistan too big.
Best chance was late 80s early 90s, Israel wanted to India pulled back. Now Israel is in range, 8 MRBMs with MRVs aimed just at Tel Aviv would be almost impossible to defend.
US option now has been to get Pak onside. Pak is too weary of that, so we are in the weird grey area where we are friendly with US but at an arms length. Suits both parties fine.
Let us also not forget now that China would not sit back and see Pakistan demolished either, US and Israeli calculations take that on board too