Not sure about this.
Although the April ceasefire was against Netanyahu’s wishes, and even these talks are, I would not say that the April ceasefire and this are against Israel. Trump (or any other administration) would never do anything against Israel.
Why isn’t the April ceasefire or these current talks against Israel? Because if Israel and the US were fighting a long war against Iran, with Israel’s (and the US’s) limited number of missile defence systems (compared to Iran’s far greater number of ballistic and cruise missiles), Israel would be facing an existential threat.
These talks are just fact facing, that the victor of the war (Iran) has to be given big concessions. But that comes at the expense of IAEA inspectors on their soil that will certainly ensure their program is strictly used for civilian purposes (enrichment levels strictly capped at 3.67%, and their HEU stockpile diluted or destroyed). That will protect Israel at least from a nuclear threat that was existential for them. The other threats from Iran (ballistic missile attacks, support to non state actors) are not existential to them.
This is similar to the JCPOA, it was never against Iran, it was always in the interest of Israel that Iran was able to enrich for civilian purposes only.
If the US actively blocked all defensive or offensive weapons sales to Israel, I’d say that would be against Israel, because Israel on its own cannot sustain itself or its wars.
