There will be no asymmetric resistance like what happened in Afghanistan.
Iranians are too Westernized, perhaps the most Westernized in the Middle East, and the Islamic Republic has less than 20% support in major cities. Now I know that people will attack me and say 20 million people did that, 10 million did this or whatever, but the truth is that dissatisfaction with the system is too high, even among its supporters.
The Islamic Republic has too many internal enemies as well, to make things worse.