Su35 are not just fighters. Are multirole fighters.
With them you can take off from any small airport inside Irán and hit land target using glide bombs or shoot down any helicopter patrolling the Straits happily as we have seen two days ago. Even with AEW coverage, those fighters can fly behind the mountains Kuh-e genu and surprise any aircraft patrolling SoH from a long distance.
You're mixing air superiority, that requires a dozen of squadron and other assets like AEW aircrafts and tankers with the tactical flexibility of having modern fighters. You have witness the utility of using some dozens of aircrafts like Ukraine does with their Mig29 fleet.
Remember also that F35 need to be close to Su35, which flies faster, higher altitude and can much easier outmatch the AIM120 amraams because they have a non scape zone smaller when used with faster aircrafts like Su35.
So even flying a F35 is not that easy to shoot down a Su35.