The route they would have to take is too challenging and might not even be possible. IMO, they really only have one route and it's a long one over Syria & Iraq. Being that Syria is not well guarded and they've essentially had full ability of violating its airspace but not necessarily the entire width from west to east which is what they'll have to do in this case. Then there's Iraq where the only way they can negotiate that airspace is not only by thwarting much of Iraq's minor existing SAM systems, but they'll also need serious coordination by the US to supply A2A refueling which means they'll be getting close to Iran's border in order to not only refuel, but to get within range of the standoff weapons they have which are essentially Delilah CMs and JDAMs (possibly JSOWs if the US has supplied them), all of which don't have extraordinary range. All that puts the pressure on the stealthiness of the F-35. In that case they'll have to penetrate Iran's air space to get close enough to designated targets due to Iran's size.
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Maybe it's over Jordan then Iraq but something tells me despite the rumors, Jordan won't allow it.
Now if Iran has anything resembling the Russian Resonance-NE or Protivnik-GE radars which detect low-observable aircraft up to 1,200km and designate several targets at 600km range, these aircraft are toast. The combination of all those factors tells me this is why there will be no attack from Israel in this manner at least and if it does happen, it will be something totally different and who knows how effective it will be.